Elizabeth was his third wife138

“[Elizabeth] married for her third husband James Eno on 5 August 1658. James Eno’s wife, Hannah (Bidwell), had died the previous year leaving him with three small children, who were subsequently raised with five of Thomas and Elizabeth’s younger children in the Holcomb house.”164

From Barbara Bartels’ notes:130
Elizabeth and Thomas Holcomb, both assumed to be passengers on the ship “Mary and John,” were married two years after their arrival in the New World. They were part of a religious group headed by the Revs. John Maverick and John Warham.

“In 1964 Jacobus noted that "[h]er maiden name has been stated as Ferguson, without proof or probability" [McArthur-Barnes 169].)”138